Muhammad Faizi
Airlangga University- Dr. Soetomo Hospital Surabaya, Indonesia
Biography:
Muhammad Faizi is currently working as Lecturer at the Department of Pediatrics, Faculty of Medicine, Airlangga University- Dr Soetomo Hospital. Surabaya, Indonesia.
Abstract:
Background: Mostly, type 1 diabetes mellitus (T1DM) is caused by pancreatic beta cell damage by autoimmune process which leads to reduced insulin production. Autoantibodies related to T1DM are islet-cell antibodies (ICA), insulin autoantibodies (IAA), tyrosine phosphatase autoantibodies (IA-2A) and glutamic acid decarboxylase (GAD). The profile of anti-glutamic acid decarboxylase autoantibodies in type 1 diabetes mellitus children in Dr. Soetomo Hospital Surabaya is still unknown.
Objective: The objective of the study is to determine the profile of anti-glutamic acid decarboxylase autoantibodies in type 1 diabetes mellitus children in Dr. Soetomo Hospital Surabaya.
Methods: This cross sectional study evaluated children with T1DM in Pediatric Endocrinology Outpatient Clinic of Dr.Soetomo Hospital during January-March 2017. We diagnosed T1DM based on consensus of Pediatric Endocrinology Working Group, Indonesian Pediatric Society. The presence of anti-GAD in serum was detected by anti-GAD65 commercial kit. Duration of illness referred to time from T1DM diagnosed until anti-GAD examination.
Results: There were 32 children with T1DM, 50% males. The mean age at diagnosis was 9.75 (SD 2.52, range 4-14) years. The median of duration of illness was 3.5 (range 1-11) years. The anti-GAD was positive in 30 (93.8%).
Conclusions: Anti-GAD test is positive in majority children with T1DM and still persist for long periods since T1DM diagnosed.